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lab:biochemistry [2013/03/20 16:17] sinatta |
lab:biochemistry [2020/06/11 10:23] (current) sinatta |
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** Head: ** M.R. Jisnuson Svasti, Ph.D. (Molecular biology)\\ | ** Head: ** M.R. Jisnuson Svasti, Ph.D. (Molecular biology)\\ | ||
- | [[lab:biochemistry:jisnuson_cv|Curriculum Vitae]]({{:lab:biochemistry:jcv45_2013_edited1.pdf| pdf to download}}) | + | Curriculum Vitae({{:lab:biochemistry:jscv50_2017_all-1.pdf| pdf to download}}) |
** Location: ** 7<sup>th</sup> Floor, Biomedical Science Building | ** Location: ** 7<sup>th</sup> Floor, Biomedical Science Building | ||
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* [[lab:biochemistry:res_act|Research Activities]] | * [[lab:biochemistry:res_act|Research Activities]] | ||
- | * [[lab:biochemistry:acad_act|Academic Activities]] | ||
* [[lab:biochemistry:staff|Contact Information & Staff List]] | * [[lab:biochemistry:staff|Contact Information & Staff List]] | ||
* [[lab:biochemistry:publications|Publications]] | * [[lab:biochemistry:publications|Publications]] | ||
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- | Proteins are the instruments through which the genetic potential of an organism is expressed. Although the sequence of the human genome offers a molecular blueprint of an organism, this information is not enough to provide detailed knowledge of how living organisms function, since the information in DNA has to be expressed through the synthesis of polypeptide chains, which may be further modified, such as by glycosylation or cleavage. Polypeptide chains must also fold to give the three-dimensional structure of the protein, which is what determines its action. We have been interested in protein structure and function for many years, and are presently interested in the changes in proteins in genetic diseases and in cancer. We have also become interested in searching for anti-cancer agents from medicinal plants, and studying how they affect the protein patterns of affected cells. Researchers in the Laboratory of Biochemistry have received various awards, such as the Outstanding Scientist of Thailand Award from the Foundation for the Promotion of Science and Technology, the Outstanding Researcher Award, Chemical Sciences and Pharmacy Section from the National Research Council of Thailand, and the Senior Research Scholar Award from the Thailand Research Fund. | + | Although the human genome sequence provides a molecular blueprint of an organism, the information encoded in DNA is not enough to understand how living organisms function, since it has to be expressed through the synthesis of proteins. Proteins may be further modified, such as by glycosylation or phosphorylation, and must fold into a complex three-dimensional structure, which makes them highly specific and efficient as biological catalysts. We have been interested in protein structure and function for many years, and have now focused our interests on the abnormalities in the amount and/or function of proteins, which can give rise to diseases, such as cancer and genetic diseases. Understanding such defects can provide important leads to devising cures for diseases and improve the quality of life of the Thai people, which is the goal of the Chulabhorn Research Institute. |
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